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  • br The introduction of direct acting antiviral drugs DAAs

    2019-05-08


    The introduction of direct-acting antiviral drugs (DAAs) is changing the treatment options for hepatitis C CGP-41251 (HCV). These new medicines were initially marketed at a very high price, but several countries have negotiated favourable price reductions, and, in view of the low cost of production, further price reductions are anticipated, especially as the result of generic competition. Reliable, transparent, and updated information about drug availability and costs are important for policymakers, procurement agencies, providers, and people living with HCV to help ensure equitable access.
    David Evans and colleagues (August, 2015) modelled how the loss of health-care workers to Ebola virus disease (EVD) might have affected infant, under 5, and maternal mortality in Guinea, Liberia, and Sierra Leone. Unfortunately, laboratory workers were not included in the health-care worker definition used in their model. Laboratory workers are a central part of an effective health system. In the same issue, Ranu Dhillon and Robert Yates propose five priorities for Ebola-affected countries. These also did not include the need for an effective public health laboratory system.
    The health workforce crisis has contributed to many countries\' inability to achieve the Millennium Development Goals, and is likely to affect the ability to achieve the Sustainable Development Goals and universal health coverage. Solutions to the workforce crisis have mainly targeted service providers (physicians, nurses, etc) by either improving the local and global supply of these workers or reducing the workload burden through task-shifting. However, focusing on service providers will not overcome crucial barriers in the implementation and scale-up of health services such as stockout of health commodities, ill-constructed facilities, and outdated information systems.
    Lancet Glob Health —In table 1 of this Article (published online Aug 14, 2015), the last sentence in the footnote should read ‘¶Prevalence data are per 100 population’. This correction has been made to the online version as of Oct 13, 2015.
    JV and SHK conceptualised and designed the INTERGROWTH-21 Project. JV, DGA, JAN, and SHK prepared the original protocol, with input from ZAB, LCI, FCB, and ATP. JV, FG, ZAB, LCI, AL, and ATP supervised and coordinated the project overall. JV, FG, EOO, DGA, and ATP were responsible for data management and analysis. EB, FCB, MGG, MP, RP, RO, and YAJ collaborated in the overall project and implemented lignin in their respective countries. JV, FG, CV, and SHK wrote the report with input from all coauthors. All authors read the report and made suggestions on its content.