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br Dihydrotestosterone in adult fish and frogs
2024-03-07
Dihydrotestosterone in adult fish and frogs New perspectives and next directions Similar to other androgens, DHT can modulate reproductive endpoints in both fish and amphibians. However, predicting the effects of DHT can be challenging, as reproductive homeostasis is dependent upon the balance
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br LOX in pancreatic cancer
2024-03-07
5-LOX in pancreatic cancer 5-LOX is a key player in pancreatic cancer (PC) progression. The upregulation of 5-LOX mRNA has been observed in pancreatic adenocarcinoma (PDAC) and also in neoplastic pancreatic tissues (Kennedy et al., 2003). Higher levels of 5-LOX transcripts (messengers) are presen
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Compounds are representatives of an array of MBG targets
2024-03-07
Compounds – are representatives of an array of MBG targets (, ) related to imidazole standard that were synthesized and initially tested in a rat CYP17 lyase screening assay (). The inhibitors were synthesized as racemates by coupling of 6,7-dimethoxy-naphthalene-2-isopropyl ketone with the requisi
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Fig summarizes the oxidative metabolism of arachidonic
2024-03-06
Fig. 1 summarizes the oxidative metabolism of arachidonic ack1 inhibitors by lipoxygenases cyclooxygenases and cytochrome P450. Lipoxygenases in humans are expressed in a tissue-specific fashion: 5-LOX is mainly expressed in leukocytes, 12-LOX in platelets, and 15-LOX-1 in reticulocytes, eosinophi
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Among all the polysaccharide derivatives cationic carbohydra
2024-03-06
Among all the polysaccharide derivatives, cationic carbohydrate polymers such as quaternary ammonium salts and quaternary phosphonium salts have been the most popular and most efficient target SC 560 in medical applications [24] and water treatment [25]. Recently, quaternary phosphonium salts were r
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Some of previous immunohistochemical studies
2024-02-23
Some of previous immunohistochemical studies have compared the levels of AR expression in low-grade versus high-grade and/or non-muscle-invasive versus muscle-invasive tumors. There was a significant or marginal decrease (Boorjian et al., 2004, Miyamoto et al., 2012b, Rau et al., 2011, Shyr et al.,
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br Materials and methods br Conflict
2024-02-23
Materials and methods Conflict of interest Acknowledgments We thank Christine Heiner (Department of Surgery, University of Pittsburgh) for her critical reading of the manuscript. This work was supported by grants from the US National Institutes of Health (R01GM115366, R01CA160417, and R01CA
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br Serine glycine and one carbon metabolism
2024-02-23
Serine/glycine and one-carbon metabolism Altered serine metabolism in tumors was noted nearly half a century ago, and elevated flux through the de novo serine synthesis pathway (SSP) is a common phenomenon in cancer Cinacalcet HCl [43]. The SSP branches from glycolysis at the point of 3-phosphog
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The dependence of blood cell production
2024-02-23
The dependence of blood cell production on a limited number of HSC and HPC (hereafter collectively referred to as HSPC) means that protection from potential toxins is essential for maintenance of the hematologic system (see Fig. 1). For example, the generation of blood cells within the intramedullar
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br ARIs in the prevention of prostate cancer Prostate cancer
2024-02-23
5ARIs in the prevention of prostate cancer Prostate cancer continues to be a leading cause of male deaths worldwide. In 2009, it was estimated there would be 192,280 new cases of prostate cancer with a predicted 27,360 deaths [25]. Because androgens, and specifically DHT, play a large role in bot
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br Consequences of central apelin APJ modulation Regarding
2024-02-23
Consequences of central apelin/APJ modulation Regarding extra-hypothalamic actions, recent data demonstrate that the central apelin/APJ system could be a potential new target for the regulation of memory (Han et al., 2014). Then, intracerebroventricular (icv) apelin administration in mice impairs
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The reduction of heterodimerization of
2024-02-23
The reduction of heterodimerization of KOR and APJ by both doses of apelin found in the present study may result in inducing protective effects of apelin on the myocardium imposed to high pressure in renovascular hypertension conditions. The finding that apelin in both doses reduced heterodimerizati
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Finally the comparison between data obtained by
2024-02-23
Finally, the comparison between data obtained by antioxidant assays in in vitro cultured cells [11], [12] and in liposomes has disclosed the possibility to choose more confidently “the better phenolipid” of a series of fatty acids esters antioxidant derivatives. Looking at the physical parameters th
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br Conclusion br Introduction Breast
2024-02-23
Conclusion Introduction Breast cancer is the most common cancer and second leading cause of cancer-related deaths in women [1,2]. There were about 1.7 million new cases of breast cancer worldwide in 2012 [3], and the number of new cases of female breast cancer is expected to increase to 3.2 mi
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br Results and discussion This paper reports
2024-02-22
Results and discussion This paper reports the synthesis of methoxy and 4-thio derivatives of quercetin and luteolin, which includes two new derivatives (4 and 12) and explores how subtle variations in the chemical structure of flavonoids affect their biological activity, particularly in relation
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