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syk inhibitor Mitochondrial dysfunction resulting from mtDNA
2023-01-09
Mitochondrial dysfunction resulting from mtDNA abnormalities may trigger retrograde signaling pathways from the mitochondrion to the nucleus, which regulate the expression of genes involved in diverse cellular processes, including metabolism, stress responses, tumor progression, nutrient sensing, li
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The efficacy of antibiotics in improving smell
2023-01-09
The efficacy of Finasteride mg in improving smell function has been previously found to be negative, both when used for bacterial and viral infections. Van Zele et al, in a double-blind, placebo-controlled, multicenter study, found no influence of doxycycline treatment on self-reported olfactory lo
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Use of RASB is associated with
2023-01-09
Use of RASB is associated with potential concerns about side effects such as acute kidney injury or hyperkalemia, and clinicians are reluctant to prescribe RASB in patients with severe renal dysfunction (estimated GFR Conclusions Conflict of interest Acknowledgement Introduction Renin-an
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Platelet derived growth factor PDGF and ciliary neurotrophic
2023-01-09
Platelet-derived growth factor (PDGF) and ciliary neurotrophic factor (CNTF) are expressed by glial n-acetyl-l-cysteine and are important to neuron survival and the maintenance of oligodendrocytes. These neurotrophic factors contribute to the remyelination process by increasing the proliferation of
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br Materials and methods br Conflict of
2023-01-09
Materials and methods Conflict of interest Acknowledgments We thank Christine Heiner (Department of Surgery, University of Pittsburgh) for her critical reading of the manuscript. This work was supported by grants from the US National Institutes of Health (R01GM115366, R01CA160417, and R01CA
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Accumulating evidence indicates that experience dependent al
2023-01-09
Accumulating evidence indicates that experience-dependent alterations in glutamate transmission in the NAc, such as those produced by repeated exposure to cocaine, involve alterations in postsynaptic signaling mediated by AMPA-type receptors (Pierce and Wolf, 2013, Wolf and Ferrario, 2010). In the N
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Therefore to better understand the
2023-01-09
Therefore, to better understand the functional properties of Peruvian infusion tea plants and provide evidence for the development of functional food supplements containing the Peruvian infusion tea plant, the aldose reductase inhibition together with the antioxidant activities of 24 selected Peruvi
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br Translational Considerations Targeting the
2023-01-09
Translational Considerations Targeting the AHR Pathway Modulating AHR function offers exciting therapeutic potential in host immunity and inflammation. However, the emerging concept of AHR function in a cell type-specific manner, combined with differences between AHR activation in cell culture in
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Our initial approach to identify hits was two pronged and
2023-01-05
Our initial approach to identify hits was two-pronged and included a high-throughput screening (HTS) campaign of the OSI Peficitinb library as well as a virtual screening (VS) campaign, utilizing a publically available crystal structure of ACK1 (PDB code: ). A tolerance for protein flexibility was
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To date the modes of actions of pharmaceuticals in humans
2023-01-05
To date, the modes of actions of pharmaceuticals in humans and mammals are well-known (Fent et al., 2006), whereas knowledge of aquatic organisms, particularly invertebrates, is limited. This is problematic as these contaminants/pollutants have potentially harmful effects on wildlife organisms that
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Additional evidence for a putative role
2023-01-05
Additional evidence for a putative role of COXs and 5-LOX in AD derives from pharmacological studies using inhibitors of these enzymes (for review, see Firuzi and Praticò, 2006). In addition to helping delineate the pathobiological mechanisms of AD, these results raise hope for discovering novel the
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As we previously observed in
2023-01-05
As we previously observed in the NSFT (Fukumoto et al., 2014), the effect of LY341495 in the FST was also inhibited by a 5-HT1A receptor antagonist, indicating the role of the 5-HT1A receptor in the actions of LY341495. Among the 5-HT1A receptors, which exist both presynaptically and postsynapticall
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br Acknowledgments br Introduction Human innate immune syste
2023-01-05
Acknowledgments Introduction Human innate immune system provides first line of defense against multiple viral or bacterial attacks, and provides critical surveillance against oncogenic development. Evidences show that individuals with primary immunodeficiency or induced immunosuppression durin
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br Acknowledgements We would like to thank
2023-01-05
Acknowledgements We would like to thank Dr. Thomas Blanpied, Sai Sachin Divakaruni, Dr. Helmut Kessels, Feline Lindhout, Dieudonnée van de Willige, and all members of the MacGillavry lab for discussions and critical reading of the manuscript. This work was supported by NWO (ALW-VENI 863.13.020, A
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TUNEL assay Apoptotic DNA fragmentation in
2023-01-05
TUNEL assay. Apoptotic DNA fragmentation in Aliskiren Hemifumarate synthesis was measured using a commercially available TUNEL assay kit (Thermo Fisher). Frozen cells were fixed with 10% paraformaldehyde/PBS. Apoptosis was determined by staining the 3′-OH ends of fragmented DNA with biotin-dNTP usi
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