• CLL associated HLH was first documented

  2019-05-20

  

  CLL associated HLH was first documented in the form of a case series report which included six patients treated for CLL who subsequently developed the phagocytic syndrome months to years later.[7] As these cases occurred prior to publication of the 1991 HLH diagnostic guidelines, the authors postula

• br Discussion Bone marrow fibrosis is known

  2019-05-20

  

  Discussion Bone marrow fibrosis is known to be associated with hematolymphoid malignancies such as acute leukemia, Hodgkin and non-Hodgkin lymphoma. Among the acute leukemias, marrow fibrosis is most often seen with acute megakaryoblastic leukemia. It is an uncommon finding in APL and till date o

• br We value the efforts

  2019-05-20

  

  We value the efforts of Akram Ahmad and colleagues (August, 2016) in highlighting an important issue related to the regulation of antibiotic fixed-dose combination drugs (FDCs) in India. Moreover, we agree with Ahmad and colleagues that actions taken by the Indian Government to ban irrational FDCs

• Atrial fibrillation AF is the most common

  2019-05-20

  

  Atrial fibrillation (AF) is the most common type of arrhythmia in developed countries. Its prevalence almost doubles with each decade of life [1], with a lifetime prevalence of 25% [2]. AF is also an important risk factor for mortality [3]. Along with stroke, heart failure (HF), which is a signific

• Biological mechanisms have also been associated

  2019-05-20

  

  Biological mechanisms have also been associated with poor cardiovascular outcomes in ICD patients with depression, such as alteration of cardiac autonomic tone, activation of the sympathetic nervous system, enhanced activity of the hypothalamic-pituitary-adrenal axis, and elevated inflammatory and p

• The starting point is to address the huge

  2019-05-18

  

  The starting point is to address the huge gap in surveillance capabilities identified in 2014 by the WHO\'s first global report on surveillance of antimicrobial resistance. To address this salt inducible kinase gap, WHO\'s action plan is being implemented in phases from early 2016 onwards, gatherin

• Introduction Brugada syndrome is severe arrhythmia character

  2019-05-18

  

  Introduction Brugada syndrome is severe arrhythmia characterized by specific ST elevations in precordial leads and sudden ventricular fibrillation (VF), and the condition may result in sudden cardiac death [1–5]. By implanting defibrillation devices, also known as implantable cardioverter-defibrill

• br Case report A year old man with a history

  2019-05-18

  

  Case report A 63-year-old man with a history of longstanding atrial fibrillation (AF) was admitted to our hospital with anterior acute myocardial infarction (AMI). Emergency cardiac catheterization revealed chronic total occlusion of the distal right coronary artery, total occlusion of the proxi

• The final variant deals with a patient

  2019-05-18

  

  The final variant deals with a patient who has a poor prognosis due to visceral metastases and who suffers from a single site of painful bone disease. The purpose of the case was to evaluate the panel\'s views of supportive care with analgesic medications plus or minus EBRT. The group did recommend

• br Benign bone tumors br Giant cell tumor of jaws

  2019-05-18

  

  Benign bone tumors Giant cell tumor of jaws [GCT] GCTs arising in the head and neck region constitute approximately 2% of all GCTs. They are locally aggressive, recurrent and non-metastasing. Neoplastic giant cell are very rare in jaws. GCT usually occurs in children and young adults, predomin

• Introduction Osteosarcoma OS is the most commonly diagnosed

  2019-05-18

  

  Introduction Osteosarcoma (OS) is the most commonly diagnosed histological form of primary bone tumor with high morbidity, and it is mainly prevalent in teenagers and young people [1]. Pain is the most common early symptom of OS and can cause fracture of the affected bone. Currently, multiple thera

• Common and rare SCN A variants may

  2019-05-18

  

  Common and rare SCN10A variants may contribute to AF susceptibility [59,60]. SCN10A mutations (R14L and R1268Q) cause a loss of function of Nav1.5 current, which is expected to reduce excitability and lead to the development of the arrhythmogenic substrate responsible for BrS and AF. A common varian

• A partir de las consideraciones que distinguen la

  2019-05-18

  

  A partir de las consideraciones que distinguen la institucionalización formal e informal, O’Donnell hace un llamado BIBF1120 tener en cuenta las especificidades de las democracias de América Latina y plantea que algunas democracias han subsistido, se han mantenido en el tiempo aun con la presencia d

• De manera puntual ambos gobiernos dejaron sentadas sus posic

  2019-05-18

  

  De manera puntual, ambos gobiernos dejaron sentadas sus posiciones ante el nuevo proceso bilateral para normalizar sus relaciones. En su alocución del 17 de diciembre de 2014, el general Raúl Castro destacó, entre otras cosas, que desde su elección como presidente de los consejos de Estado y de Mini

• Any abnormality causing a loss of

  2019-05-17

  

  Any abnormality causing a loss-of-function in the IKs macromolecular complex may lead to adrenergic-induced imbalance in ventricular repolarization currents and consequent QTc prolongation, which is identified based on the defective response of IKs to PKA stimuli due to mutations in KCNQ1 (-G269S, -

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