• The modification of proteins with

  2021-03-29

  

  The modification of proteins with the small 76-amino 3934 protein ubiquitin (Ub) plays a central role in many key cellular processes. Ubiquitylation of a target protein requires the concerted action of a cascade of three enzymes (Figure 1). The ubiquitin-activating enzyme (E1) catalyzes the formatio

• To study the role of DNA

  2021-03-29

  

  To study the role of DNA–PK in the response to replication arrest, we used the DNA replication inhibitor aphidicolin (APH). APH, a mycotoxin isolated from Cephalosporium aphidicola, inhibits DNA replication by interacting with the replicating DNA polymerase α (pol α). APH specifically inhibits the a

• ASC was reported as a potent

  2021-03-29

  

  ASC was reported as a potent antiviral and antifungal agent, and its derivatives could modulate a variety of physiological activities, such as anti-tumor, anti-metastatic, and anti-diabetic activities in animals. Mie Tsuruga et al. found that 4-o-methylascochlorin had immunosuppressive activity, but

• In this study EDC NHS

  2021-03-29

  

  In this study, EDC/NHS crosslinked collagen films were derivatised with VWFIIINle-containing THPs and the effect on VWF and DDR2 activity was examined. First, we investigated restoration of the binding of DDR2 and VWF A3. Cell behavior beyond simple binding was also investigated through DDR2 ARCA sy

• Ligand independent constitutively active variants have

  2021-03-29

  

  Ligand-independent, constitutively active variants have also been found in receptors with associated tyrosine kinases. In approximately 60% of patients harboring inflammatory hepatocellular adenomas (IHCAs), these adenomas have been caused by small in-frame deletions in the cytokine-binding domain o

• A 77636 hydrochloride Proteolysis by CPs is crucially import

  2021-03-29

  

  Proteolysis by CPs is crucially important for cereal seed development and germination. However, these enzymes must be tightly controlled. Pre-harvest sprouting is a phenomenon in which the control of CPs is disrupted. This disruption manifests in the premature synthesis and activation of CPs, leadin

• In addition to the blockade of airway

  2021-03-29

  

  In addition to the blockade of airway smooth muscle contractions, CysLT1 receptor antagonists also exerted a potent anti-inflammatory effect at this level. The oral administration of MEN91507, Pranlukast, Montelukast, and Zafirlukast also produced a long-lasting inhibition of leukotriene D4-induced

• Ultimately we decided to investigate the role of Cyp

  2021-03-29

  

  Ultimately, we decided to investigate the role of Cyp3a in obesity because Hepatic P450 Reductase-null (HRN) mice with no P450 activity show hepatic steatosis with increased Cyp2b10 and Cyp3a11 expression, perturbations in liver size, lipid homeostasis, and increased liver polyunsaturated fatty acid

• Based on both the observational

  2021-03-29

  

  Based on both the observational and theoretical data generated in this study, it appears that the mechanism(s) underlying lower IFM CPT1 activity is complex. Modeling enzyme activity versus alterations in catalytic efficiency (Fig. 3A) suggests that the observed age-associated changes in Km and Vmax

• Application of the CPH model relies on the assumption that

  2021-03-29

  

  Application of the CPH model relies on the assumption that the hazard ratio of two observations is constant over time [2]. This enables us to infer the rate of risk of the treatment. For example, in the study of patients with pulmonary arterial hypertension (PAH) [5], the hazard ratio of a group of

• While lowering the TID exposure of electronics is fairly str

  2021-03-29

  

  While lowering the TID exposure of electronics is fairly straightforward, there are other EIPA synthesis induced effects that are not as easily mitigated, especially with COTS components. Single Event Effects (SEE) occur when a high-energy particle strikes the active area of an integrated circuit, c

• Mass spectrometry has previously been used to examine the

  2021-03-29

  

  Mass spectrometry has previously been used to examine the presence of Hyp in recombinant collagen, using hydrolysates to identify the individual imino acid, equivalent to an amino LY2090314 analysis [33], and also by analysis of mass changes to tryptic peptides [34]. The present study, however, has

• Nelfinavir Mesylate No effect on the A production by secreta

  2021-03-29

  

  No effect on the Aβ production by γ-secretase was observed at 50μM, the highest effective concentration used in cultured Nelfinavir Mesylate by the study of Flajolet et al. IC261 did also not exert a modulatory effect on the production of Aβ, Aβ and Aβ species in the cell-free assay at this concentr

• The use of recombinant ER and ER

  2021-03-29

  

  The use of recombinant ERα and ERβ binding assays offers a relatively inexpensive, rapid technique for screening compounds for potential direct calcitonin receptor receptor modulatory activity and understanding the mechanisms of existing herbal medicines. For background on the protein production sy

• A French cohort study reported that micronized progesterone

  2021-03-29

  

  A French cohort study reported that micronized progesterone or didrogesterone used with oral or percutaneous estradiol showed no increase or decrease in the risk of breast cancer compared to synthetic progestins for at least 4 years of treatment [22] and even after 8 years [23]. Although the results

14961 records 624/998 page Previous Next First page 上5页 621622623624625 下5页 Last page