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T cell infiltration is an
2019-07-02
T cell infiltration is an important predictive biomarker for the PD-1 blockade, and it is closely associated with a good prognosis. In our study, we found that T cells were low and exhausted within the tumor microenvironment and were distributed in the tumor margin. Anti-PD-1 treatment reduced PD-1
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Colony stimulating factor receptor CSF R or cFMS is a
2019-07-02
Colony stimulating factor-1 receptor (CSF-1R or cFMS) is a type III receptor tyrosine kinase. It is activated by binding with CSF-1 and IL-34, which stimulates differentiation, proliferation, survival and migration of monocyte-macrophage lineage cells., , , Also, macrophages produce inflammatory me
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Based on the finding described
2019-07-02
Based on the finding described above, the present study was designed to investigate the effects of specific CRF receptors, CRF1 and CRF2, in the BLA and CeA on the duration of TI in guinea pigs (Cavia porcellus). To this end, we evaluated whether administration of the CRF1 Prostaglandin E2 of antag
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br Methods Ventricular cardiomyocytes from adult male Wistar
2019-07-02
Methods Ventricular cardiomyocytes from adult male Wistar rats were isolated using a standard enzymatic digestion [11]. Cells were incubated at 37°C for 4 to 6h with Tyrode solution (in mM: 140 NaCl, 4 KCl, 1.1 MgCl2, 10 HEPES, 10 glucose, 1.8 CaCl2; pH7.4, with NaOH) supplemented or not with 10μ
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Sodium Aescinate of br Experimental procedures br Results
2019-07-02
Experimental procedures Results Fluorescence attributable to GnRH-eGFP neurons was observed through the diagonal band of Broca, to the POA of the hypothalamus in GnRH-eGFP transgenic rats for all groups as described previously (Kato et al., 2003, Tada et al., 2013). Discussion The mEPSCs w
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Univariate analysis for overall survival revealed that age y
2019-07-01
Univariate analysis for overall survival revealed that age (≤, >50 years), menopausal status, T-N stage, and histological tumor size were statistically significant factors for survival. Menopausal status was determined after two years of amenorrhea. In post-menopausal women, the disease-free surviva
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br Conflict of interest br
2019-07-01
Conflict of interest Acknowledgments Introduction Electroanatomical mapping is useful for locating a possible reentrant circuit, but it has limitations in terms of analyzing the functional property of the circuit [1,2]. Entrainment mapping using the postpacing interval (PPI) and the activat
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br Discussion SIS is a morphological characteristic
2019-07-01
Discussion SIS is a morphological characteristic of the basal interventricular septum that protrudes into the LV cavity. This cardiac malformation has generally been considered a natural part of aging without pathophysiological or clinical significance [5,6]. However, several studies demonstrated
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In a recent study Nademanee et al reported additional
2019-07-01
In a recent study, Nademanee et al. [76]. reported additional evidence pointing to pathologic changes in the RVOT of patients with BrS that have proved undetectable by echocardiography or MRI. In contrast, imaging techniques in ARVC clearly display morphologic and functional changes (e.g., dilation
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gli1 Article of the Universal Declaration of Human Rights st
2019-07-01
Article 25 of the Universal Declaration of Human Rights states that “everyone has the right to a standard of living adequate for the health and well-being of himself and of his family, including food, clothing, housing and medical care and necessary social services, and the right to security in the
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apigenin structure br Maternal and Child Nutrition Series
2019-07-01
Maternal and Child Nutrition Series noted the emergence of overweight and obesity in low-income and middle-income countries while also documenting the unfinished agenda in undernutrition, sometimes in the same countries and populations. Furthermore, the Series reported analyses of data from Brazil
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Si consideramos el estado incipiente de la discusi n alreded
2019-07-01
Si consideramos el estado incipiente de la discusión alrededor de este concepto emergente, veremos que un análisis cualitativo más detallado de los textos constitucionales resulta bastante prometedor. Bolivia En el caso boliviano, buen vivir aparece como parte esencial de la refundación del Esta
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br Discussion In this pilot study we
2019-07-01
Discussion In this pilot study, we report that sequential treatment of low dose clofarabine and lenalidomide is safe and feasible for elderly patients with high risk MDS and AML. Only one subject developed dose limiting toxicity (liver dysfunction) from lenalidomide consolidation therapy. Pre-tre
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Funding NIH K AI PATH Gates Foundation UW MSRTP AOA
2019-06-29
Funding NIH K23-AI103105, PATH, Gates Foundation 50274, UW MSRTP, AOA Carolyn Kuckein Fellowship, IDSA Medical Scholars. Declaration of interests Abstract Background Safe, timely and accessible global essential surgery and anaesthesia, once neglected in global health, is now an integral part of
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A facility survey from reported that
2019-06-29
A facility survey from 2003 reported that GX15-070 only 15% of primary health centres provided abortion services. Another study from Rajasthan state revealed that nine districts included 83% of all facilities whereas the remaining 22 districts included only 17%. Within districts too, abortion facil
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