• Bioinformatics tools are becoming more powerful and

  2025-01-13

  

  Bioinformatics tools are becoming more powerful and reliable due to the growing number and availability of experimentally determined protein structures (Arnold et al., 2006, Suplatov et al., 2015, Wiltgen and Tilz, 2009). The SWISS-MODEL and MODELLER programs are most frequently used for homology or

• histone acetyltransferase br Concluding remarks Enhanced mem

  2025-01-13

  

  Concluding remarks Enhanced membrane binding upon calcium stimulation in histone acetyltransferase suggests a pre-requisite step that involves a conformational change in LOX. This might facilitate it to tether to the membrane and regulate enzyme activity. The calcium binding loops and the putati

• br Role of OCT in histamine

  2025-01-13

  

  Role of OCT3 in histamine clearance Histamine is a powerful neuromodulator, as well as a regulator of immune processes and vascular tone in the central nervous system (Gross, 1981; Haas et al., 2008; Jutel et al., 2006). In contrast to 5-HT and the catecholamines, a high-affinity transporter for

• Since the cloning of ARs in the beginning of

  2025-01-13

  

  Since the cloning of ARs in the beginning of the 1990s, the efforts to characterize them have led to the accumulation of a substantial amount of experimental data. Decades of site-directed mutagenesis (SDM; Box 1) studies, in combination with pharmacological data and computational modeling, have pav

• Additionally regulation of GPCR heteromerization by specific

  2025-01-13

  

  Additionally, regulation of GPCR heteromerization by specific ligands may depend not only on the affinity of ligands for receptors, but also on presence of different interacting proteins co-localizing with the receptors in the specific cell, which may induce some conformational changes and contribut

• Normally the activity of the lyase increases with the onset

  2025-01-13

  

  Normally, the activity of the 17,20-lyase increases with the onset of adrenarche [7], [8], [15]. Adrenarche has previously been perceived as a relatively sudden event, occurring physiologically between 6 and 8years of age. However, results from our laboratory clearly indicated that adrenarche is a c

• Matsuzaki et al attempted fertility therapy in

  2025-01-13

  

  Matsuzaki et al. attempted fertility therapy in a 26-year-old female with secondary amenorrhea and 17OHD who was a ACE2 Pathway heterozygote for delF53/54 and the missense mutation H373L, which has cycle supports this theory. Oocyte dysfunction with decreased granulosa cell activity might also contr

• br Author contributions br Conflict of interest br Acknowled

  2025-01-13

  

  Author contributions Conflict of interest Acknowledgements This work was supported by the National Natural Science Foundation of China (81502276), Major Projects of Science and Technology of Health and Family Planning Commission of Hunan Province (A2017013), the Natural Science Foundation o

• Comparison of the GLUT positive plus

  2025-01-13

  

  Comparison of the GLUT1-positive plus ACLY negative group with the GLUT1-negative plus ACLY positive group indicated no significant difference with respect to disease-free survival and overall survival. However, some obvious differences in histological types were found in their formation. A previous

• Co is an essential element

  2025-01-10

  

  Co is an essential element for life in minute amounts [5]. The human adult contains about 1.1mg Co with the daily requirement of 0.1μg/day. Co is a component of vitamin B12. Co induces erythropoietin and blocks iodine uptake by the thyroid, controls the transfer of enzymes like homocysteine methyltr

• br Acknowledgments br Protein microarrays were developed to

  2025-01-10

  

  Acknowledgments Protein microarrays were developed to provide miniaturized high-throughput tools to study protein function, TAE684 and post-translational modifications. Just a few years ago, the seminal work performed in Stuart Schreiber's laboratory at Harvard University () and at Michael Sny

• The proposed method was also

  2025-01-10

  

  The proposed method was also used to evaluate resistance to natamycin (a natural antibiotic produced by Streptomyces natalensis used for fungal control on cheese surface) of 9 fungi, including those previously mentioned as well as Phoma pinodella UBOCC-A-116004, Candida parapsilosis UBOCC-A-216002,

• Complementing the effects of ARB and ACEI on HDL

  2025-01-10

  

  Complementing the effects of ARB and ACEI on HDL capacity to elicit cholesterol efflux, HDL of ARB- and ACEI-treated groups significantly lessened macrophage production of superoxide (Fig 2). As with efflux, there was no difference in this effect between the ARB and ACEI groups. These data are inter

• br Introduction Breast cancer is

  2025-01-10

  

  Introduction Breast cancer is the most frequently occurring cancer in women, and despite the development of new therapies there has been little decline in the mortality rate over the past decade (Siegel et al., 2015). This is partly due to the genetic diversity of breast cancers, such that there

• acetylcholine receptor Liver plays a pivotal role in metabol

  2025-01-10

  

  Liver plays a pivotal role in metabolism of xenobiotic compounds, such as environmental contaminants and drugs. Some of these compounds generate hepatic damage and impair its function. It was well-known that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) could induce pathological changes in mouse and ra

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