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Another topic for research will be the combination
2024-04-23
Another topic for research will be the combination of other cytotoxic agents with Aurora kinase inhibitors. Particularly interesting might be the combination of Aurora kinase inhibitors and agents that depend on the spindle checkpoint for their activity, such as the taxanes, given the importance of
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Several in vivo and in vitro studies have demonstrated chang
2024-04-23
Several in vivo and in vitro studies have demonstrated changes in bioactive lipid profiles under hyperglycemic conditions and have linked these changes with increased leukocyte adhesion and vascular dysfunction during diabetes. This input has originated partly from lipidomic studies that showed elev
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The growth of cancer can control by inhibiting the
2024-04-23
The growth of cancer can control by inhibiting the rate of cell proliferation or increasing the rate of selective apoptosis and effectiveness of anticancer agents varies according to genetic constitution of cancer. Hence, we investigated the anticancer activity of arginase against different kinds of
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Similar to other MADS box proteins MEF factors associate
2024-04-23
Similar to other MADS box proteins, MEF2 factors associate with a variety of transcriptional cofactors to control specific sets of downstream target genes. Some of the cofactors such as MyoD, GATA4, NFAT, TH receptor, p300, 14.3.3 and ERK5 stimulate MEF2 activity, whereas others, such as HDACs4-5-7-
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Plant pathogenic fungi have caused
2024-04-23
Plant pathogenic fungi have caused a lot of economic losses to agricultural production worldwide every year. It is necessary to develop an bio-sourced antifungal agent for agricultural use. Many researches have shown that the antifungal activity of quaternized chitosan derivatives is mainly affected
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On the other hand oxygen concentration
2024-04-23
On the other hand, oxygen concentration in tumor tissue also depends on its consumption rate by tumor cells, which decrease will also lead to alleviation of hypoxia. This fact is not taken into account in the majority of studies on the topic, although it is well-known that antiangiogenic therapy doe
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br Materials and methods br Results
2024-04-23
Materials and methods Results Discussion We have in this study used semi-nested degenerative PCR to identify the lipoxygenases expressed in the lung tissue from M. fascicularis and report on the identification of 5- and 12/15-LO transcripts from this tissue. Although we did not find transcr
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Some of the earliest LOX inhibitors were redox inhibitors in
2024-04-23
Some of the earliest 12-LOX inhibitors were redox inhibitors, including nordihydroguaiaretic pd 0332991 (NDGA), BW 755C, and baicalein 48, 49, 50. Redox inhibitors block the oxidation of the nonheme iron at the cataylytic site, preventing its conversion from the inactive (Fe2+) to the active (Fe3+)
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Recently two distinct small molecule inhibitors of PHGDH
2024-04-23
Recently, two distinct small-molecule inhibitors of PHGDH were identified using high-throughput screens, both of which inhibit de novo serine biosynthesis and show selective toxicity to cancer Cy7 NHS ester (non-sulfonated) with high SSP flux [50,51]. The inhibitor NCT-503, which has an IC50 of 2.5
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br We approached the definition of AD
2024-04-23
We approached the definition of AD with the distinction between a syndrome and a disease in mind. Some will argue that a specific syndrome, that is, a multidomain amnestic dementia (after other potential etiologies have been excluded), should define AD in living people. Our position, however, is t
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So far many independent studies
2024-04-23
So far, many independent studies have linked cholesterol metabolism–related genes with AD, either by showing associations with specific polymorphisms or with differential bethanechol chloride synthesis levels (Beecham et al., 2014, Blain and Poirier, 2004, Lambert et al., 2009, Lambert et al., 2013
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Therefore to better understand the functional
2024-04-23
Therefore, to better understand the functional properties of Peruvian infusion tea plants and provide evidence for the development of functional food supplements containing the Peruvian infusion tea plant, the aldose reductase inhibition together with the antioxidant activities of 24 selected Peruvi
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Studies on both TCDD treated mice and AhR null mice
2024-04-23
Studies on both TCDD treated mice and AhR null mice have also pointed to a role of AhR in hematopoiesis [65], [66]. Singh et al. showed that AhR is a negative regulator of HSC (hematopoietic stem cell) proliferation, while deletion of AhR leads to spleen enlargement in juvenile and adult mice [67].
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According to average serum fat content
2024-04-23
According to average serum fat content of 6.9 g/L (Phillips et al., 1989) and serum dioxin level from individuals exposed to dioxins as the result of accidents in Seveso (Needham et al., 1997), Taiwan (Guo et al., 2004) and Vietnam (The Tai et al., 2011) the median serum concentration of TCDD would
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There is a growing literature on ABCA expression in
2024-04-23
There is a growing literature on ABCA2 expression in human biopsies, where it has been described as a potential biomarker of leukemias. In childhood T-cell acute lymphoblastic leukemia, ABCA2 and ABCA3 were expressed at high levels, which upon treatment with methotrexate, vinblastine and doxorubicin