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HEK cells stably transfected with CysLT
2019-11-06
HEK-293 A-1155463 stably transfected with CysLT1 were stimulated with LTD and internalization was studied by confocal microscopy, FACS or cell-surface ELISA. Cells were co-transfected with wildtype and dominant negative (DN) mutants of arrestin and dynamin. Clathrin-mediated endocytosis was invest
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luciferin definition The role of ARA cyp metabolites
2019-11-06
The role of ARA-cyp450 metabolites in the liver is still unclear [44]. However, ARA-cyp450 genes metabolize other fatty acids such lauric and palmitic luciferin definition [45]. It was found that decreased cyp4a expression caused fatty livers through reduction of fatty acid metabolism [46]. In this
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In the present study real time polymerase chain reaction
2019-11-06
In the present study, real-time polymerase chain reaction also confirmed that gene expressions of RT1 class II, locus Bb (RT1-Bb) was up-regulated and Spi-B transcription factor (Spib) was downregulated at day 3 after the VMH lesions. These two genes work as one of immune responses. RT1-Bb controls
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In addition to tissue resident stromal and myeloid cell popu
2019-11-06
In addition to tissue-resident stromal and myeloid cell populations, ILCs also readily engage in positive-feedback loops with myeloid NCT-503 recruited from the circulation. TNF-α produced by inflammatory monocytes recruited to the lungs of mice infected with Klebsiella pneumoniae markedly increase
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Introduction Innate lymphoid cells ILCs are recently describ
2019-11-06
Introduction Innate lymphoid Leupeptin (ILCs) are recently described immune cells of lymphoid origin and include cytotoxic natural killer (NK) cells and interleukin-7 receptor alpha (also known as CD127)+ subsets, which, similar to T helper (Th) lymphocytes, can be distinguished on the basis of si
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Cellular immune responses such as phagocytosis and
2019-11-06
Cellular immune responses, such as phagocytosis and apoptosis, are very important processes to eradicate the invading pathogens and reduce concomitant host damage. And all of these processes are fine-tuned by the ubiquitin system (Li et al., 2016). Phagocytosis is a major mechanism of cellular immun
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In plants SUMOylation has been shown to modulate plant hormo
2019-11-06
In plants, SUMOylation has been shown to modulate plant hormone signaling (Lois et al., 2003, Miura et al., 2009, Conti et al., 2014), root stem cell maintenance (Xu et al., 2013), and responses to abiotic and biotic stress (Lois, 2010). Many of the plant biological processes regulated by SUMOylatio
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Cancer has been linked to both genetic and epigenetic
2019-11-06
Cancer has been linked to both genetic and epigenetic changes. Epigenetic modifications, mainly DNA methylation at CpG dinucleotides, affect the regulation of gene transcription without altering the gene\'s sequence. Short sequences rich in CpG dinucleotides (i.e., CpG islands) are often found in th
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Introduction The inflammation process involves sequential ac
2019-11-06
Introduction The inflammation process involves sequential activation of signaling molecules, pro-inflammatory mediators, such as prostaglandins, leukotrienes, and oxygen free radicals [1]. Two cyclooxygenases MLN 8237 were responsible for activation of the production of prostaglandins (PG1s) and o
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The ESC update emphasizes the need for implementing strategi
2019-11-06
The 2017 ESC update emphasizes the need for implementing strategies to minimize PCI-related complications, including risk stratification for ischemia and bleeding, keeping triple antithrombotic therapy to the shortest possible duration with dual antithrombotic therapy as an alternative, using non–vi
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br O GlcNAcase Human OGA is a multidomain protein
2019-11-06
O-GlcNAcase Human OGA is a multidomain protein with an N-terminal domain similar to glycoside hydrolase family 84 (GH84) enzymes, a stalk domain, a C-terminal pseudo histone acetyltransferase (HAT) domain, and several low-complexity regions (Figure 1f) [43]. A splice variant that lacks the HAT do
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The Wnt signaling pathway has been demonstrated to be respon
2019-11-05
The Wnt signaling pathway has been demonstrated to be responsible for a variety of biological processes. The three best-characterized Wnt signaling pathways are the canonical Wnt pathway, the noncanonical planar cell polarity pathway, and the noncanonical Wnt/calcium pathway. The canonical Wnt/β-cat
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As for antiviral activity eight out of
2019-11-05
As for antiviral activity, eight out of 23 synthesized compounds were active against influenza B virus with EC50 values in the range of 0.19–39 μM. Four of the eight influenza B hits were active against influenza A and two were also active against RSV (4 and 6, EC50 = 0.40 and 1.8 μM, respectively).
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br Subjects and methods br Results br Discussion In the
2019-11-05
Subjects and methods Results Discussion In the present study, we found significantly increased CSF levels of IL-4, IL-5, IL-9, IL-10, TNF-α, CXCL8/IL-8, and VEGF-A together with significantly higher detection rates of IL-6, GM-CSF, PDGF-BB and IL-1ra in IHP patients compared with OND patien
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br Methods br Results br Discussion With this study
2019-11-05
Methods Results Discussion With this study, we provided evidence that acriflavine can interfere with EMT and UPR, two well-described pathways associated with cancer aggressiveness. And, because drug resistance is also clearly associated with the mesenchymal state [36], blocking of the epith
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