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The effect of combined A and PD
2022-06-18
The effect of combined A-192621 and PD 155080 treatment on the alverine during endotoxin infusion is quite different compared to either drug used alone (Wanecek et al., 1999). After administration of both antagonists in combination, cardiac index increased to baseline values within 30 min, and was
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It is important to mention that the IC of cetirizine
2022-06-18
It is important to mention that the IC50 of cetirizine needed to achieve histamine H2 receptor desensitization was 0.43 µM or 170 ng/ml (Fig. 1B), becoming clinically relevant since pharmacokinetic studies after oral administration of the clinically used dose (10 mg/day) reported a maximal plasma co
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This study was supported by the Finance
2022-06-18
This study was supported by the Finance Department Foundation of Jilin Province (3D5178963428). Introduction Breast cancer is one of the leading cause of death in women worldwide [1,2]. Due to recent advances of combined therapies, survival rate of breast has improved significantly. However, bre
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It is not established if
2022-06-18
It is not established if ONOO− also induces tyrosine nitration of ANT and affects VDAC1 and ANT interaction, as well as the interaction of VDAC1 with HK II, all of which are events that may lead to altered mitochondrial and cellular function. Thus, in this study we examined tyrosine nitration of bot
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Starting from the hypothesis that
2022-06-18
Starting from the hypothesis that the linker portion of the inhibitor molecules does not necessarily require the presence of an alcohol/ether or a carbonyl group, the same research group performed another scaffold hopping analysis, obtaining 1500 new compounds as potentially active HO-1 inhibitors [
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Background Chronic hepatitis C virus HCV infection
2022-06-18
Background Chronic hepatitis C virus (HCV) infection is a major public health concern, with 71 million people infected worldwide [1]. Treatment options have improved with the availability of interferon-free direct-acting antiviral (DAA) therapies with cure in >95% of people [2]. However, broadening
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There is increased awareness of HBV reactivation in chronic
2022-06-18
There is increased awareness of HBV reactivation in chronic HCV/HBV co-infected patients treated with DAAs [1], [2]. The recent emergence of this adverse event of DAA therapy is due to the exclusion of HBV co-infected subjects from registration clinical trials evaluating the safety of these treatmen
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br Materials and methods br Results br Discussion To underst
2022-06-18
Materials and methods Results Discussion To understand the molecular basis for how ghrelin secretion is regulated at the cellular level, we identified the full repertoire of 7TM receptors and G proteins in gastric ghrelin Fludarabine Phosphate and functionally characterized the majority of
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Curcumin is the active ingredient extracted
2022-06-17
Curcumin is the active ingredient extracted from the natural medicine turmeric rhizome (Goel et al., 2008, Aggarwal and Harikumar, 2009). Studies have shown that curcumin has anti-tumor, anti-inflammatory, antioxidant and antimicrobial properties (Larsen et al., 2007, López-Lázaro, 2008). Although c
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In humans the effect of
2022-06-17
In humans, the effect of GnRH and hCG on trophoblast invasion was found to be mediated through extracellular matrix remodeling by facilitating the activity of MMP2 and MMP9 [13], [18], [44]. Both Caspase-8 Colorimetric Assay Kit are collagenases that degrade extracellular matrix. In canines, this
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Due to the therapeutic potential of GlyT
2022-06-17
Due to the therapeutic potential of GlyT1 inhibitors, numerous drug screening campaigns have been started - and are still going on - which aimed at the identification of compounds with biological activity at or affinity for this drug target. For characterization of biological activity at GlyT1, tran
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Also considered very rare is progressive
2022-06-17
Also considered very rare is progressive encephalomyelitis with rigidity and myoclonus (PERM); sometimes called Stiff Person Syndrome Plus (SPS Plus) and with antibodies to glutamic BMS-754807 mg decarboxylase (GAD). However, PERM is now increasingly found with glycine receptor antibodies (GlyR-Ab)
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The observed increase in macroscopic conductance could be du
2022-06-17
The observed increase in macroscopic conductance could be due to a left shift in the open state probability vs. voltage curve for the high-activity state causing an increase in the open state probability at all potentials. However, an increase of the apparent single channel conductance cannot be ent
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In this study we intended to
2022-06-17
In this study, we intended to explore the efficacy of artesunate on liver fibrosis and further clarify its potential molecular mechanism. Artemisinin, a sesquiterpene lactone obtained from a Chinese plant Artemisia annua [27]. Artesunate, as a stable derivative of artemisinin, is an effective drug f
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Reserpine hydrochloride Histamine modulates an attentional s
2022-06-16
Histamine modulates an attentional state, which might affect performances in the object recognition test. Indeed, systemic injection of H3 receptor inverse agonists enhances the attentional state (41). However, the memory recovery in our study is unlikely to be due to the enhanced attentional state.
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