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br Materials and methods Male Sprague Dawley rats
2022-03-14
Materials and methods Male Sprague–Dawley rats (Faculty of Pharmacy, Pharos University, Alexandria, Egypt) weighing 180 to 200g were used in this study. All experiments were performed in strict accordance with institutional animal care and use guidelines. Results Discussion The current stu
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br Methods br Results br Discussion In the general
2022-03-14
Methods Results Discussion In the general population BNP has been established as a marker for Puromycin receptor failure diagnosis. Moreover, there is growing evidence that elevated levels of natriuretic-peptides may improve CV risk prediction in the general population above traditional ri
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According to previous methods several mobile
2022-03-14
According to previous methods, several mobile phase compositions and gradient programmes were assayed to get the best resolved peaks for HA and MHA [12], [13], [24]. Considering the slightly structural differences of the analytes, a mobile phase consisting in two eluents of different polarity and pH
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br Competing interests br Funding br Ethical approval br
2022-03-14
Competing interests Funding Ethical approval Acknowledgement Introduction Hepatitis C is a disease that infects the liver through transmission of the hepatitis C virus (HCV). Because the symptoms of this infection are not pronounced, the infected individuals may not even be aware of t
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No other lacZ mutant showed a marked difference in mutation
2022-03-12
No other lacZ mutant showed a marked difference in mutation rate between fpg and fpg backgrounds (that is, rates were comparable between HS101 and CSH1191, HS102 and CSH1192, etc.). The number of reversion mutants was much higher in HS1194 than in any other fpg strain. The inclusion of the pTRC99a p
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br Methods and materials br Results and discussion br Conclu
2022-03-12
Methods and materials Results and discussion Conclusions This is the first study that attempted to isolate, purify and identify the characteristics of YM201636 from ginseng. In vitro studies have demonstrated that PGL-1 efficiently suppressed SH-SY5Y cell apoptosis induced by Aβ25–35, possi
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Sepsis was defined as a systemic
2022-03-12
Sepsis was defined as a systemic inflammatory response syndrome (SIRS) associated with severe infection in 1992 [9]. However, in the Third International Consensus Definitions for Sepsis and Septic Shock [10], it was redefined as life-threatening organ dysfunction provoked by a dysregulated host resp
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Assuming thus a positive signal for both GLUT and GLUT
2022-03-12
Assuming thus a positive signal for both GLUT1 and GLUT3 in our conditions, a more detailed explanation of the results observed through immunocytochemistry is needed. In this way, it must be reminded that syncytiotrophoblasts compose the outer layer of the trophoblast, are in direct contact with mat
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Limitations of our study are the following we
2022-03-12
Limitations of our study are the following: we did not measure central energy metabolism in parallel, so we can only hypothesize that GLUT1 hypermethylation may be associated with alterations in central glucose metabolism. We did not measure GLUT1/GLUT4 gene expression or glucose uptake, so that we
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Here we used chemogenetic modulation of MBH GHSR neurons to
2022-03-12
Here, we used chemogenetic modulation of MBH GHSR neurons to address the role of the endogenous ghrelin system in the normal, hyperphagic response to a short-term fast. Studies demonstrating the requirement of an intact ghrelin-GHSR system for the rebound food intake following fasting have been inco
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Cx has been shown to
2022-03-12
Cx45 has been shown to be serine phosphorylated by CaMKII, CK1, PKA, and MAPK in HeLa AGN 194310 [77], [78]. Phosphorylation by PKA and MAPK were associated with decreased junctional conductance [78], suggesting that phosphorylation of Cx45 may influence conduction properties. Overall, the roles of
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Based on the above considerations
2022-03-12
Based on the above considerations, the β-galactosidase gene from Exiguobacterium acetylicum MF03 (not previously reported) was cloned, expressed and purified with the aim of assessing the potential of this novel enzyme for catalyzing reactions of synthesis and hydrolysis of glycosides. Because of E.
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In the intestine ethanol exposure can change the
2022-03-12
In the intestine, ethanol exposure can change the composition of gut microbiota and promotes the growth of intestinal gram-negative bacteria, which results in the accumulation of endotoxins such as, LPS. Ethanol also impacts the integrity of the gastrointestinal mucosal barrier, increasing intestina
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Several transgenic and knockout congenic mouse models have b
2022-03-12
Several transgenic and knockout/congenic mouse models have been generated in order to assess the role of FFAR1 for proper insulin secretion and maintenance of glucose homeostasis. The results obtained with three different receptor knockout mouse models were not consistent. The protection against hig
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br STAR Methods br Introduction Arsenite is
2022-03-12
STAR★Methods Introduction Arsenite is a well-recognized toxic metalloid that commonly presents in the natural environment. Chronic exposure to arsenite can lead to a wide range of adverse health effects to human, including cancers, cardiovascular diseases, diabetes, skin lesion and neurodegene
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