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For another the N terminal sequence of native glucagon
2022-01-15
For another, the N-terminal sequence of native glucagon is highly conserved, and positions 8, 9, 16 and 18 are noteworthy in maintaining glucagon activity [18], [20], [21]. It also achieves a degree of selectivity from its C-terminal residues, and a significant contribution is made by the C-terminal
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In summary our findings provide the evidence and the mechani
2022-01-15
In summary, our findings provide the evidence and the mechanistic understanding of the protective effects of GIP receptor agonist, D-Ala2GIP, in the MPTP-induced neurotoxicity in mice. The observed protective effects are potentially due to reduced oxidative stress and attenuation of dopamine loss in
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Ghrelin is mostly known for its
2022-01-15
Ghrelin is mostly known for its orexigenic properties, whereas the role of DAG on feeding is controversial with studies claiming an orexigenic, anorexigenic or no effect (Inhoff et al, 2009, Toshinai et al, 2006). One of these studies was that of Toshinai and colleagues, who found a link between the
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br Structures of human secretase Before the near
2022-01-15
Structures of human γ-secretase Before the near-atomic resolution structures, the highest resolutions achieved for γ-secretase were 15 and 12Å [19, 21]. The 15-Å structure revealed a HyperScribe Poly (A) Tailing Kit chamber in the transmembrane domain and two pores at the top and bottom of γ-sec
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To date types of glucose
2022-01-15
To date, 14 types of glucose transport protein have been discovered, each having its own specific functions with different distributions [33]. Among these, GLUT4 is particularly important for maintaining glucose metabolism homeostasis and insulin sensitivity, since it is involved in glucose transpor
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br Materials and methods br Results
2022-01-14
Materials and methods Results Discussion FFAR4 is a G-protein coupled free fatty BMS-303141 receptor that has been reported to be expressed in osteoclasts and osteoblasts [18]. In this study the role of FFAR4 on the effects of different classes of UFAs, the ω−6 PUFA, AA, the ω−3 PUFAs, DHA
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BDNF is intricately implicated in
2022-01-14
BDNF is intricately implicated in energy homeostasis (Hamdouchi et al., 2016; Schwartz and Mobbs, 2012), regulation of mood (Sartorius et al., 2015) and adult neurogenesis (Taliaz et al., 2010; Waterhouse et al., 2012), our primary focus was to evaluate the effects of GPR40 stimulation on BDNF expre
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br RESULTS br DISCUSSION In this
2022-01-14
RESULTS DISCUSSION In this study, we found impaired apoptosis in the peripheral blood of RA patients when compared with peripheral blood from normal controls. Our previous studies have shown that the number of CD4 + T Metronidazole increased while regulatory T (Treg) cells diminished in the p
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Over decades a deeper understanding of terpene synthases has
2022-01-14
Over decades, a deeper understanding of terpene synthases has also permitted enzyme engineering for unnatural substrate acceptance. Novel terpenoids have been successfully synthesized from substrate analogues as by-products from mechanistic investigation (Faraldos et al., 2012; Miller, Yu, & Alleman
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In summary we have provided evidence that TA a
2022-01-14
In summary, we have provided evidence that TA, a novel HATi, inhibits the acetylation of histone and non-histone proteins and activation of the mRNA expression of lipogenesis-related genes both in vitro and in vivo (Figure 8), indicating that inhibition of HAT activity by TA is necessary for the pre
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Second although HO expression in
2022-01-14
Second, although HO-1 expression in the stromal macrophages has been seen in the other cancer tissues [21], the impact of HO-1 expression on EAOC progression has not been explored. We have found that the CD163+ M2-like Berberine Sulfate were HO-1+ in OE, but malignant transformation may be associat
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br Autophagy and HBV induced HCC
2022-01-14
Autophagy and HBV-induced HCC Researchers have demonstrated downregulation of autophagy in HBV transgenic liver tumors of mouse models and in human HBV-induced HCC specimens. Kotsafti and his colleagues declared that the expression level of BECN1 mRNA in HCC specimens was considerably lower than
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In conclusion three heat stable cyclic peptides guanylin
2022-01-14
In conclusion, three heat-stable cyclic peptides, guanylin, uroguanylin and renoguanylin are expressed in the intestine and kidney of the European eel, Anguilla anguilla. Their physiological functions are likely to be mediated, at least in part, by two isoforms of the guanylate cyclase type C recept
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This variant has also been related to a better
2022-01-14
This variant has also been related to a better treatment response in patients with metastatic colorectal cancer subjected to irinotecan-based chemotherapy (Kweekel et al., 2008). Inheritance of this metabolic variability has also been stated to influence better treatment outcomes in breast cancer pa
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br GSNOR regulates SA synthesis and SA signalling
2022-01-14
GSNOR1 regulates SA synthesis and SA signalling The phenolic metabolite salicylic sirtuin (SA) is a powerful immune activator in plants. Moreover, mutations that disable SA biosynthesis or transgenes that result in its depletion compromise both resistance (R) gene-mediated and basal resistance,
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