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br Method br Results br Discussion
2022-01-13
Method Results Discussion There were two major sources of fluorescent signals of NADH in the mouse retina. One was a product derived from glutamate and the other was the elevation of intrinsic NADH. In the present study, we observed significant contamination from intrinsic NADH in “the oute
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Artemisinine It raises a question about
2022-01-12
It raises a question about origin of the sensitivity to Ca of both FBPase isozymes. Was the ancestral vertebrate FBPase inhibited by calcium similarly to the liver isozyme? And is the high sensitivity of FBP2 a new evolutionary feature of warm-blooded vertebrates? Additionally, since subcellular lo
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br Materials and methods br Results br Discussion
2022-01-12
Materials and methods Results Discussion In the absence of vascularization phenomena, endothelial cells (ECs) are among the most quiescent cells of the body [27]. ECs proliferation is significant during embryogenesis, as the vasculature is being formed, while in the adult life takes place o
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The other possibility for the
2022-01-12
The other possibility for the lack of effects of H1 receptor agonists, e.g. histamine, on the NMDAR-mediated responses is that other neurotransmitters may cause more profound effects than histamine on the gliotransmitter release from astrocytes. For example, recent studies showed that noradrenaline,
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br Discussion Light plays a central role in plant growth
2022-01-12
Discussion Light plays a central role in plant growth, development and defence responses. It is required for photosynthesis and other metabolic or transcriptional processes (Kangasjärvi et al., 2012, Zhang and Zhou, 2013, Ballaré, 2014). It is well known that darkness promotes leaf senescence, wh
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Background Chronic hepatitis C virus HCV infection is a majo
2022-01-12
Background Chronic hepatitis C virus (HCV) infection is a major public health concern, with 71 million people infected worldwide [1]. Treatment options have improved with the availability of interferon-free direct-acting antiviral (DAA) therapies with cure in >95% of people [2]. However, broadening
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We have shown previously that
2022-01-12
We have shown previously that activation of the TGFβ/Smad signaling pathway in keratinocytes regulates Tubacin cytoskeleton organization via non-genomic and genomic mechanisms and that RhoB gene is a target of Smad proteins [12,13]. Although the role of RhoB in early non-genomic TGFβ-induced cell r
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Calyculin A mg At days and hours after MI the protein expres
2022-01-12
At 21 days and 24 hours after MI, the protein expressions of active JNK1 (P Calyculin A mg of p38 was down-regulated only at 21 days after MI (P Discussion This study demonstrates the role of GSTP1 in HF by inhibiting the TRAF2-induced MAPK activation and the potent inhibitory effect of GSTP1 on
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Increasing number of experimental data reveal
2022-01-12
Increasing number of experimental data reveal that both ROS and RNS are multifunctional molecules playing a substantial role in plant physiology and particularly in seed biology (Bailly et al., 2008; Šírová et al., 2011; Yu et al., 2014). Dual function of RNS can be described by the model of “nitros
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Finally the results in this
2022-01-11
Finally, the results in this article indicate that atomistic MD in conjunction with computational electrophysiology and ion-permeation simulations provide a useful tool for the functional annotation of ion-channel structures. In particular, they exemplify how MD simulations in native lipid membranes
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br Materials and methods br
2022-01-11
Materials and methods Results Discussion l-glutamate is the major excitatory neurotransmitter in the brain, and is functionally involved in many processes of the nervous system which have been connected with several neurological diseases [4]. These conditions are characterized by the time-d
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There are two ways to transport FFAs into cells
2022-01-11
There are two ways to transport FFAs into cells. First by passive diffusion. Second as the putative long-chain fatty Tylosin tartrate transporters are proposed, CD36 the plasma membrane-associated fatty acid-binding protein (FABPpm) and fatty acid transport proteins (FATP) [11], where CD36 is respon
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br Materials and methods br Results br Discussion
2022-01-11
Materials and methods Results Discussion Although homologues of the β-galactosidase gene were known to exist in the Xenopus genome, and SA-β-gal activity has been detected in whole-mount Xenopus embryos by histochemical staining (Davaapil et al., 2017), no reports have been presented so far
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In addition to the type of food consumed also
2022-01-11
In addition to the type of food consumed, also the effect of calorie restriction (CR), i.e. an intermittent fasting and re-feeding cycles with concomitant fluctuations in the level of glucose and insulin, can affect the course of IBS through the modulation of the BA homeostasis. This type of nutriti
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Corresponding to the different insulinotropic signaling the
2022-01-11
Corresponding to the different insulinotropic signaling, the competitive radioligand-binding studies demonstrated at least 3 distinct CCT251545 on GPR40: orthosteric binding site for endogenous ligands, allosteric binding site for partial agonists and another allosteric binding site for full agonis
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