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The inhibitory concentration of atrial natriuretic factor at
2021-10-21
The 50% inhibitory concentration of atrial natriuretic factor at midgestation and term are –7.4 ± 0.12 and –7.38 ± 0.11, respectively, demonstrating no gestational age dependency in the effect of atrial natriuretic factor on spontaneous contractile activity. Diethyl amine/nitric oxide starts to inh
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Glutathione transferases GST have been
2021-10-20
Glutathione transferases (GST) have been discovered in many tissues including the cornea of humans and several other mammals (Awasthi et al., 1980, Bilgihan et al., 2003; Gondhowiardjo and van Haeringen, 1993; Saneto et al., 1982, Sastry et al., 1995, Singh et al., 1985, Watkins et al., 1991). To da
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We have previously established the
2021-10-20
We have previously established the pharmacokinetic profile and effective dose of MNF in the rat [43] and demonstrated the effectiveness of MNF as an anticancer drug in Mometasone furoate australia and xenograft models [44]. Moreover, MNF was found to effectively block GPR55 signaling in tumor cells
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shows the hormonal and follicular growth profile of the woma
2021-10-20
shows the hormonal and follicular growth profile of the woman who ovulated in both cycles. In cycle 1, an LH surge occurred on day 17, when serum oestradiol concentration was 210.5 pg/ml and follicle diameter 17 mm. In cycle 2, ganirelix administration was continued until day 19 instead of until th
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We have previously designed an
2021-10-20
We have previously designed an azobenzene-based molecule, Razo, which could switch the conformations of G-quadruplex structures by photoregulation. 12, 13, 14, 15 However, it lacks selectivity to different G-quadruplexes. Therefore, we want to find a way to modify this molecule so that it could be u
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One may ask whether induced loss through
2021-10-20
One may ask whether induced loss, through chemical or genetic perturbation for example, of an essential cellular factor represents regulated cell death or simple loss of the homeostasis needed for life. For example, deletion of the Mdm2 gene, or inhibition of the MDM2 protein, results in cell death
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br Materials and methods br Results
2021-10-20
Materials and methods Results To examine the apoptosis in FLS in vitro, we measured the number of filipin in early apoptosis (Annexin V+, 7-AAD−) and late apoptosis/necrosis (Annexin V+, 7-AAD+) using flow cytometry after incubation with or without stimulating Fas antibody. In the absence of
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To evaluate the role of
2021-10-20
To evaluate the role of increased FPPS expression in paclitaxel-treated cells, we investigated the effects of FPPS on apigenin progression. DNA content analysis showed that the number of cells accumulating in the G/M phase increased in a dose-dependent manner in paclitaxel-treated cells (A and B),
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Interestingly evidence has emerged recently that
2021-10-20
Interestingly, evidence has emerged recently that suggests noncanonical roles of EZH2 in various cancers. For example, in addition to histone H3, EZH2 has been shown to methylate non-histone substrates, such as Jarid2 and STAT3, to regulate their transcriptional activities (He et al., 2012, Sanulli
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br Introduction Ovarian cancer patients have the
2021-10-20
Introduction Ovarian cancer patients have the highest mortality rate amongst patients with gynecologic cancers. The 10-year survival rate of ovarian cancer patients is cancer p53 pathway with BRCA1/2 mutation [2]. Several studies have indicated the role of dysregulation of histone methylation i
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Recently the toxicity of TBT was demonstrated at the vascula
2021-10-20
Recently, the toxicity of TBT was demonstrated at the vascular level in animal models (Nath, 2008), and the results obtained so far suggest that TBT may be a potential risk factor for cardiovascular diseases. TBT is capable to alter the coronary vascular reactivity to estradiol (dos Santos et al., 2
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The rationale for developing HDACi as anticancer
2021-10-20
The rationale for developing HDACi as anticancer agents was based on their ability to induce the hyperacetylation of histones and nonhistone proteins, resulting in increased differentiation, apoptosis, and kisspeptin arrest of cancer cells 1, 2, 3. HDACi have been used in the treatment of hematolog
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Different SVR rates have been observed when
2021-10-20
Different SVR rates have been observed when comparing GT 1a- and 1b-infected patients receiving BOC or TLP therapy. The response rates in patients infected with GT 1b have generally been more favourable than in those with GT 1a [26]. In our study, persistence mutations were only observed in HCV GT 1
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Stability of DBS over the
2021-10-20
Stability of DBS over the 60-day time points was encouraging, with a maximum of 0.1 log10 IU/mL degradation from the day 1 value (Supplementary Fig. 1 and Supplementary Table 3). Discussion This study evaluated the sensitivity and specificity of the Aptima HCV Dx assay for HCV RNA detection from
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Glycogen synthase kinase GSK is an evolutionarily conserved
2021-10-20
Glycogen synthase kinase-3β (GSK-3β) is an evolutionarily conserved serine/threonine kinase that plays multifaceted role in diverse cellular and neurophysiological processes [8]. GSK-3β is regulated by inhibitory serine and stimulatory tyrosine phosphorylation on Ser9 and Tyr216 respectively [9]. Dy
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