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In conclusions MPE effects in causing lesser
2023-12-18
In conclusions, MPE effects in causing lesser increase in vaginal fluid pH could partly restore the vaginal acidity in sex-steroid deficient state. MPE could exert its effect via enhancing both H+ generation as well as H+extrusion into the vaginal lumen. Although gallic statins hmg coa reductase in
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br Materials and methods br
2023-12-18
Materials and methods Results and discussion During recent years, recombinant ASK1 has been obtained by expensive baculovirus-insect cell Benzamil systems [20], [27]. In the present study, we constructed recombinant ASK1 and expressed in active form at high level in E. coli. Human ASK1 catal
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In order to determine whether the faster Rh
2023-12-18
In order to determine whether the faster Rh2-induced apoptosis is specific of cholesterol depletion, we determined the cytotoxic effect of Rh2 in VU 0155069 synthesis depleted or not in sphingomyelin, another abundant plasma membrane lipid exhibiting enrichment in lipid rafts. We showed that, in co
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It has been demonstrated that the hallmarks
2023-12-18
It has been demonstrated that the hallmarks of pulmonary fibrosis are a loss of endothelial function and subsequent activation of the immune system, which is considered as a direct outcome affected by intracellular pro-inflammatory responses [26]. Thus, inhibition of early inflammation could be an i
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Our previous study showed that TRIM
2023-12-18
Our previous study showed that TRIM31 could target TSC1-TSC2 complex and contributed to the clinical cancer progression [6]. In this study, we showed that TRIM31 could directly target p53 for ubiquitous degradation and further mediated anoikis-resistance of HCC cells. To further clarify the role of
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WKY and SHR strains have important differences mainly in
2023-12-18
WKY and SHR strains have important differences mainly in their sympathetic status but also in the activity of the RAS. The development of hypertension in SHR is clearly related to an increase in sympathetic activity [51], [11]. In addition, increased renal sympathetic nerve activity led to an increa
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To date LOX is the only LOX isoform
2023-12-18
To date, 12-LOX is the only LOX isoform that has been identified in the platelet [17]. Interestingly, while 12-LOX is highly expressed (∼14000 molecules/platelet) in the platelet, 12(R)-LOX expression is absent in the hematopoietic lineage and has therefore not been reported to be expressed in plate
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Several ceritinib resistant mutations following the second l
2023-12-16
Several ceritinib-resistant mutations following the second-line treatment of ALK+-NSCLC have been discovered [64]. These mutations include C1156Y, F1174L, and L1152R, which were first observed in crizotinib-resistant tumor samples. The G1202R ceritinib-resistant mutation occurs within the hinge and
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Cells have developed strategies aiming to enhance both the
2023-12-16
Cells have developed strategies aiming to enhance both the efficiency of proteins with chaperone activity as well as their overall antioxidant capacity to maintain proteostasis under oxidative stress conditions (Miyata et al., 2012). For instance, 2-Cys peroxiredoxin is an abundantly expressed, anti
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Curcumin is able to upregulate the protein level of NGF
2023-12-16
Curcumin is able to upregulate the protein level of NGF through cannabinoid receptor CB1, where the activation of Akt pathway probably plays an important part in the CB1-mediated signal transmission [9,10]. This finding suggested that the protection of curcumin in spinal motor neurons of SNI rats is
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The study by Lo http www apexbt
2023-12-16
The study by Lowry et al. (2001) pointed toward functionally uncharacterized DA- and 5-HT-accumulating neurons within the DMH as a potential target for rapid nongenomic effects of CORT. Similar DA- and 5-HT-accumulating systems are distributed throughout the central and peripheral nervous systems, s
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A selected set of these new derivatives was then used
2023-12-16
A selected set of these new derivatives was then used for functional assays at the human A1AR showing, as expected, an antagonist profile with IC50 values at nanomolar level. The same molecules showed also to be efficacious as nanomolar antagonists in a functional assay aimed at analyzing their abil
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In the presence of detrimental conditions such
2023-12-16
In the presence of detrimental conditions, such as inflammation, hypoxia, ischemia trauma or neoplastic milieu, the extracellular levels of adenosine increase massively, reaching micromolar range [51,52]. In these pathological contexts, adenosine accumulation stems from increased extracellular depho
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ADA catalyzes the deamination of
2023-12-16
ADA catalyzes the deamination of adenosine and deoxyadenosine into their respective inosine nucleoside (Cristalli et al., 2001). This conversion is an initial step in a series of reactions responsible for lymphocyte proliferation and differentiation. Moreover, ADA is considered an indicator of cellu
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teva 3026 Our initial approach to identify hits was two pron
2023-12-16
Our initial approach to identify hits was two-pronged and included a high-throughput screening (HTS) campaign of the OSI teva 3026 library as well as a virtual screening (VS) campaign, utilizing a publically available crystal structure of ACK1 (PDB code: ). A tolerance for protein flexibility was i
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